Molecular Movement of the Voltage Sensor in a K Channel

@article{Broomand2003MolecularMO,
  title={Molecular Movement of the Voltage Sensor in a K Channel},
  author={Amir Broomand and Roope M{\"a}nnikk{\"o} and H. Peter Larsson and Fredrik Elinder},
  journal={The Journal of General Physiology},
  year={2003},
  volume={122},
  pages={741 - 748}
}
The X-ray crystallographic structure of KvAP, a voltage-gated bacterial K channel, was recently published. However, the position and the molecular movement of the voltage sensor, S4, are still controversial. For example, in the crystallographic structure, S4 is located far away (>30 A) from the pore domain, whereas electrostatic experiments have suggested that S4 is located close (<8 A) to the pore domain in open channels. To test the proposed location and motion of S4 relative to the pore… CONTINUE READING

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