Molecular Motors: Turning the ATP motor

@article{Cross2004MolecularMT,
  title={Molecular Motors: Turning the ATP motor},
  author={Richard L. Cross},
  journal={Nature},
  year={2004},
  volume={427},
  pages={407-408}
}
  • R. L. Cross
  • Published 29 January 2004
  • Physics, Education
  • Nature
A long-standing question regarding ATP synthase — a cellular energy-generator — has been which direction it spins in when generating ATP. Some elegant experiments have revealed the answer. 
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Direct evidence for the chemical synthesis of ATP driven by mechanical energy is presented and shows that a vectorial force working at one particular point on a protein machine can influence a chemical reaction occurring in physically remote catalytic sites, driving the reaction far from equilibrium.
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This work incorporated double-labeled F0F1-ATP synthases from Escherichia coli into liposomes and measured single-molecule fluorescence resonance energy transfer (FRET) during ATP synthesis and hydrolysis.
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