Molecular Mimicry toBorrelia burgdorferi: Pathway to Autoimmunity?

  title={Molecular Mimicry toBorrelia burgdorferi: Pathway to Autoimmunity?},
  author={Devin D. Bolz and Janis J. Weis},
  pages={387 - 392}
Lyme borreliosis is due to infection with the tick-borne spirochete Borrelia burgdorferi, and is associated with persistent infection unless treated with antibiotics. The persistent nature of infection by B. burgdorferi can lead to development of chronic disease, as found in patients infected before recognition of the effectiveness of antibiotic therapy. Much speculation has surrounded the possibility that autoimmune mechanisms are involved in chronic symptoms. In most cases, involvement of… 

Polymyositis–dermatomyositis and infections

Evaluated studies suggest immune response abnormalities and immunosuppressive medications may be responsible for the high percentage of infectious complications in PM and DM patients, and the increased risk of developing infections in these patients is underlined.

Differential diagnoses of suspected Lyme borreliosis or post-Lyme-disease syndrome

Patients with previous suspected or diagnosed Lyme borreliosis and Borrelia-associated diseases were rare in this study and differential diagnoses helped to initiate a successful disease-specific therapeutic strategy.

Lyme Disease in Humans.

Current knowledge regarding the ecologic, epidemiologic, microbiologic, and immunologic facets of Lyme disease are integrated into a conceptual framework that sheds light on the disorder that healthcare providers encounter.

Borrelia burgdorferi surface-localized proteins expressed during persistent murine infection and the importance of BBA66 during infection of C3H/HeJ mice

The association of select genes historically categorized into pgf 54 with infectious phenotypes, with the borrelial sigma factor cascade, and the localization of their encoded proteins to the outer surface of the bacterial cell demonstrates that they are regulated by the ƒaN-ƒAS cascade.

Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection

Results demonstrate that B. burgdorferi can withstand antibiotic treatment, administered post-dissemination, in a primate host, and raises important questions about the pathogenicity of antibiotic-tolerant persisters and whether or not they can contribute to symptoms post-treatment.

Neuropathogenicity of non-viable Borrelia burgdorferi ex vivo

Non-viable B. burgdorferi can continue to be neuropathogenic to both CNS and PNS tissues with effects likely more profound in the former, and Persistence of remnant-induced neuroinflammatory processes can lead to long term health consequences.

Glomerulonephritis Associated with Other Bacterial Infections

The renal biopsy findings of postinfectious glomerulonephritis prompt a search for infectious organism in elderly patients, especially those with comorbid conditions, and there may be a role for immunosuppressive therapy in severe crescentic glomerumul onephritis or if pauci-immune glomeral morphology is a consideration.

Late Disseminated Lyme Disease Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques

The notion that chronic Lyme disease symptoms can be attributable to residual inflammation in and around tissues that harbor a low burden of persistent host-adapted spirochetes and/or residual antigen is supported.

Infections, connective tissue diseases and vasculitis.

This review focuses on the possible role of infectious agents as triggers of autoimmunity in systemic lupus erythematosus, polymyositis-dermatomyositis, antiphospholipid antibody syndrome, and primary vasculitis.



Seronegative Lyme Arthritis caused by Borrelia garinii

A case of a female patient suffering from Lyme arthritis (LA) without elevated antibody levels to Borrelia burgdorferi sensu lato is reported, which was resistant to the first treatment with antibacterial agents.

Treatment resistant Lyme arthritis caused byBorrelia garinii

Clinical and biological data did not differ from the usual descriptions of Lyme arthritis, but as the recently reported molecular mimicry between OspA and hLFA1 is not applicable to B garinii, the pathogenesis of the present cases remains unclear.

Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis.

Molecular mimicry between a dominant T cell epitope of OspA and hLFA-1 may be an important factor in the persistence of joint inflammation in genetically susceptible patients with treatment-resistant Lyme arthritis.

Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.

Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes, and identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.

Chronic Lyme borreliosis in the laboratory mouse.

The results indicate that immunocompetent mice sustain persistent infections and develop early acute joint and heart lesions that resolve and then recur intermittently.

Borrelia burgdorferi genes selectively expressed in the infected host.

  • K. SukS. Das E. Fikrig
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1995
An immunological screening strategy was used to select microbial genes expressed only in the host to identify genes induced in vivo in a wide variety of pathogenic microorganisms for which a gene transfer system is not currently available.

Induction of an outer surface protein on Borrelia burgdorferi during tick feeding.

In vitro growth experiments find that spirochetes in the midgut of ticks that have fully engorged on mice now have OspC on their surface, indicating that two environmental cues, an increase in temperature and tick feeding, trigger a major alteration of the spirochetal outer membrane.

Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency.

These studies show that specific immunity is not involved in arthritogenesis or genetically determined susceptibility to arthritis, but is involved in arthritis and carditis regression.

Borrelia burgdorferi OspA is an arthropod-specific transmission- blocking Lyme disease vaccine

OspA immunity appears to be effective only during a narrow window time at the beginning of the blood meal when antibodies bind to OspA-expressing spirochetes in the tick gut and block transmission from the vector to the host.

Fate of Borrelia burgdorferi DNA in tissues of infected mice after antibiotic treatment.

The ability to amplify B. burgdorferi DNA quickly disappeared from tissues that had become culture-negative after antibiotic treatment, suggesting that serial study of PCR-positive tissues and fluids may be useful for evaluating the efficacy of antibiotic therapy in human Lyme disease.