Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

@article{Moore1996MolecularMO,
  title={Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV},
  author={Patrick S. Moore and Christopher Boshoff and Robin A. Weiss and Yuan Chang},
  journal={Science},
  year={1996},
  volume={274},
  pages={1739 - 1744}
}
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains… 
Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines.
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human
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Contribution of Viral Mimics of Cellular Genes to KSHV Infection and Disease
TLDR
The molecular biology of K SHV homologues of cellular products as conduits of virus/host interaction with a focus on identifying new strategies for therapy of KS and other KSHV-related diseases is discussed.
Viral IL-6-Induced Cell Proliferation and Immune Evasion of Interferon Activity
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Viral IL-6 bypasses the gp80 regulatory checkpoint by binding directly to the gp130 transducer molecule, resulting in tumor cell autocrine dependence on the viral cytokine for proliferation and survival.
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