Molecular Medicine in Practice Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1 a and Transcriptional Upregulation of MAT 2 A in Hepatoma Cells

@inproceedings{Liu2011MolecularMI,
  title={Molecular Medicine in Practice Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1 a and Transcriptional Upregulation of MAT 2 A in Hepatoma Cells},
  author={Quanyan Liu and Lisheng Liu and Yuhong Zhao and Jin Zhang and Dongfeng Wang and Jiwei Chen and Yueming He and Jianguo Wu and Zhonglin Zhang and Zhisu Liu},
  year={2011}
}
Hypoxia-inducible factor 1 (HIF-1) emerges as a crucial player in tumor progression. However, its role in hepatocellular carcinoma (HCC), especially its relation with global DNAmethylation patterns in HCC under hypoxic tumor microenvironment is not completely understood. Methionine adenosyltransferase 2A (MAT2A) maintains the homeostasis of S-adenosylmethionine (SAM), a critical marker of genomic methylation status. In this study, we investigated the link between HIF-1a and MAT2A as a mechanism… CONTINUE READING
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