Molecular Medicine Arrestin Orchestrates Crosstalk Between G Protein–Coupled Receptors to Modulate the Spatiotemporal Activation of ERK MAPK


G protein– coupled receptors (GPCRs) respond to diversified extracellular stimuli to modulate cellular function. Traditionally, activated receptors couple to G proteins, which transduce downstream signals via second messengers and membrane channels. 1 Active GPCRs are phosphorylated by specific GPCR kinases (GRKs) leading to receptor desensi-tization… (More)


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