Molecular Mechanisms of Vitamin D Action

  title={Molecular Mechanisms of Vitamin D Action},
  author={Mark R. Haussler and Grahame Whitfield and Ichiro Kaneko and Carol A. Haussler and D Hsieh and Jui-Cheng Hsieh and Peter W Jurutka},
  journal={Calcified Tissue International},
The hormonal metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR). When occupied by 1,25D, VDR interacts with the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1,25D. By recruiting complexes of either coactivators or corepressors, ligand-activated VDR-RXR modulates the transcription of genes encoding proteins that… CONTINUE READING
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Nuclear vitamin D receptor: natural ligands, molecular structure–function, and transcriptional control of vital genes

  • MR Haussler, GK Whitfield, CA Haussler, J-C Hsieh, PW Jurutka
  • 2011
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