Molecular Mechanisms of Treg-Mediated T Cell Suppression

@inproceedings{Schmidt2012MolecularMO,
  title={Molecular Mechanisms of Treg-Mediated T Cell Suppression},
  author={Angelika Schmidt and Nina Oberle and Peter Heinrich Krammer},
  booktitle={Front. Immun.},
  year={2012}
}
CD4(+)CD25(high)Foxp3(+) regulatory T cells (Tregs) can suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert autoimmune disease and allergies. On the other hand, Tregs can prevent immune reactions against tumors and pathogens. Despite the importance of Tregs, the molecular mechanisms of suppression remain incompletely understood and controversial. Proliferation and cytokine production of CD4(+)CD25(-) conventional T cells… CONTINUE READING
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N. Isakov, A. Altman
Immunity • 2002
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