Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

@inproceedings{Tai2018MolecularMO,
  title={Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases},
  author={Yu Tai and Qingtong Wang and Heinrich Korner and Lingling Zhang and Wei Wei},
  booktitle={Front. Pharmacol.},
  year={2018}
}
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two activating signals are necessary steps that lead to T cell activation. The formation of stimulatory IS involves the inclusion of costimulatory molecules, such as ICAM-1/LFA-1 and… CONTINUE READING
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