Molecular Mechanisms of Resistance to Tumour Anti-Angiogenic Strategies

Abstract

Tumour angiogenesis, described by Folkman in the early seventies, is an essential, complex, and dynamic process necessary for the growth of all solid tumours. Among the angiogenic factors secreted by the tumour cells, the Vascular Endothelial Growth Factor (VEGF) is one of the most important. Most types of human cancer cells express elevated levels of this… (More)
DOI: 10.1155/2010/835680

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