Molecular Mechanisms of IgE Class Switch Recombination.

Abstract

Immunoglobulin (Ig) E is the most tightly regulated of all Ig heavy chain (IgH) isotypes and plays a key role in atopic disease. The gene encoding for IgH in mature B cells consists of a variable region exon-assembled from component gene segments via V(D)J recombination during early B cell development-upstream of a set of IgH constant region CH exons. Upon… (More)
DOI: 10.1007/978-3-319-13725-4_2

Topics

3 Figures and Tables

Cite this paper

@article{Tong2015MolecularMO, title={Molecular Mechanisms of IgE Class Switch Recombination.}, author={Pei Ying Tong and Duane R. Wesemann}, journal={Current topics in microbiology and immunology}, year={2015}, volume={388}, pages={21-37} }