Molecular Mechanisms of Exon Shuffling: Illegitimate Recombination

@article{vanRijk2004MolecularMO,
  title={Molecular Mechanisms of Exon Shuffling: Illegitimate Recombination},
  author={Anke van Rijk and Hans Bloemendal},
  journal={Genetica},
  year={2004},
  volume={118},
  pages={245-249}
}
Illegitimate recombination (IR) is a process that takes place far more often than homologous recombination and is characterized by the recombination between non-homologous or short homologous sequences. The consequences of IR frequently emerge after the introduction of DNA in cell lines because it more frequently integrates in non-homologous than in homologous regions of the host genome. As a result, unexpected truncated or elongated products may be found. By not discarding those products as… 
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