Molecular Mechanisms of Antibacterial Multidrug Resistance

@article{Alekshun2007MolecularMO,
  title={Molecular Mechanisms of Antibacterial Multidrug Resistance},
  author={M. Alekshun and S. Levy},
  journal={Cell},
  year={2007},
  volume={128},
  pages={1037-1050}
}
Treatment of infections is compromised worldwide by the emergence of bacteria that are resistant to multiple antibiotics. Although classically attributed to chromosomal mutations, resistance is most commonly associated with extrachromosomal elements acquired from other bacteria in the environment. These include different types of mobile DNA segments, such as plasmids, transposons, and integrons. However, intrinsic mechanisms not commonly specified by mobile elements-such as efflux pumps that… Expand

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