Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia

@article{Sutton2001MolecularMU,
  title={Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia},
  author={Michael A Sutton and Sarah E Masters and Martha W Bagnall and Thomas J. Carew},
  journal={Neuron},
  year={2001},
  volume={31},
  pages={143-154}
}

Figures from this paper

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References

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Dynamics of Induction and Expression of Long-Term Synaptic Facilitation in Aplysia
TLDR
The hypothesis that LTF is not a simple elaboration of STF is supported, raising the possibility that STF, ITF, and LTF may reflect components of different memory phases in the intact animal.
Coincident induction of long-term facilitation in Aplysia: cooperativity between cell bodies and remote synapses.
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Evidence is presented here that if Aplysia sensory neuron somata and their remote motor neuron synapses are simultaneously exposed to serotonin pulses insufficient to induce long-term facilitation (LTF) at either site alone, processes activated at these sites interact to induce LTF.
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A cellular analog of a classical conditioning protocol produces short-term associative plasticity at the connections between sensory and motor neurons in Aplysia and long-term enhancement of excitatory postsynaptic potentials (EPSPs).
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TLDR
Because 5-HT mediates short-term facilitation through adenosine 3',5'-monophosphate (cAMP)-dependent protein phosphorylation, the role of cAMP in the long-term modulation of this identified synapse was examined.
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
IN both vertebrates and invertebrates, long-term memory differs from short-term in requiring protein synthesis during training1,2. Studies of the gill and siphon withdrawal reflex in Aplysia indicate
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