Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia

  title={Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia},
  author={Michael A Sutton and Sarah E Masters and Martha W Bagnall and Thomas J. Carew},

Figures from this paper

Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia I: Intermediate-Term Memory1
This work has incorporated the temporal and molecular features of these different forms of ITF at tail SN-MN synapses into behavioral analyses, and found that they accurately predict distinct forms of intermediate-term memory for sensitization of the tail-elicited siphon withdrawal reflex.
Intermediate-Term Memory for Site-Specific Sensitization in Aplysia Is Maintained by Persistent Activation of Protein Kinase C
It is shown that a single tail shock can also induce ITM that is expressed selectively at the trained site (site-specific ITM), which is phenotypically similar to the form of ITM induced by repeated trials, but the mechanisms by which site- specific ITM is induced and maintained are distinct.
Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica.
Data support the hypothesis that sensory neuron activity coincident with the last RT training trial is sufficient to convert the molecular signaling already established by RT training into an AD-like molecular phenotype.
The roles of MAPK cascades in synaptic plasticity and memory in Aplysia: facilitatory effects and inhibitory constraints.
The roles of MAPK cascades in synaptic plasticity and memory for sensitization in Aplysia are summarized.
Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia.
  • C. M. Sherff, T. Carew
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
The findings show that different temporal and spatial patterns of 5-HT induce specific temporal phases of long-lasting facilitation in parallel by engaging different cellular and molecular mechanisms.
Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia.
Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in Aplysia
Evidence is provided that MAPK plays important roles specifically in long-lasting phases of synaptic plasticity and memory.
Inhibition of Conditioned Stimulus Pathway Phosphoprotein 24 Expression Blocks the Development of Intermediate-Term Memory in Hermissenda
Results demonstrate that the synthesis of Csp24 is required for the development and maintenance of intermediate memory, a characteristic of short-term memory.


Dynamics of Induction and Expression of Long-Term Synaptic Facilitation in Aplysia
The hypothesis that LTF is not a simple elaboration of STF is supported, raising the possibility that STF, ITF, and LTF may reflect components of different memory phases in the intact animal.
Coincident induction of long-term facilitation in Aplysia: cooperativity between cell bodies and remote synapses.
Evidence is presented here that if Aplysia sensory neuron somata and their remote motor neuron synapses are simultaneously exposed to serotonin pulses insufficient to induce long-term facilitation (LTF) at either site alone, processes activated at these sites interact to induce LTF.
Long-term synaptic changes produced by a cellular analog of classical conditioning in Aplysia.
A cellular analog of a classical conditioning protocol produces short-term associative plasticity at the connections between sensory and motor neurons in Aplysia and long-term enhancement of excitatory postsynaptic potentials (EPSPs).
cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis.
Because 5-HT mediates short-term facilitation through adenosine 3',5'-monophosphate (cAMP)-dependent protein phosphorylation, the role of cAMP in the long-term modulation of this identified synapse was examined.
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
IN both vertebrates and invertebrates, long-term memory differs from short-term in requiring protein synthesis during training1,2. Studies of the gill and siphon withdrawal reflex in Aplysia indicate