Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation.

@article{Tassoni2015MolecularMM,
  title={Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation.},
  author={Alessia Tassoni and Alex Gutteridge and Amanda C. Barber and Andrew Osborne and Keith R Martin},
  journal={Stem cells},
  year={2015},
  volume={33 10},
  pages={3006-16}
}
A variety of diseases lead to degeneration of retinal ganglion cells (RGCs) and their axons within the optic nerve resulting in loss of visual function. Although current therapies may delay RGC loss, they do not restore visual function or completely halt disease progression. Regenerative medicine has recently focused on stem cell therapy for both neuroprotective and regenerative purposes. However, significant problems remain to be addressed, such as the long-term impact of reactive gliosis… CONTINUE READING
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