• Corpus ID: 52225560

Molecular Mechanism of Transition from Catch-Bond to Slip-Bond in Fibrin

  title={Molecular Mechanism of Transition from Catch-Bond to Slip-Bond in Fibrin},
  author={Rustem I. Litvinov and Olga Kononova and Farkhad Maksudov and Artem A. Zhmurov and Kenneth A. Marx and John W. Weisel and Valeri Barsegov},
  journal={arXiv: Biological Physics},
The lifetimes of non-covalent A:a knob-hole bonds in fibrin probed with the optical trap-based force-clamp first increases ("catch bonds") and then decreases ("slip bonds") with increasing tensile force. Molecular modeling of "catch-to-slip" transition using the atomic structure of the A:a complex reveals that the movable flap serves as tension-dependent molecular switch. Flap dissociation from the regulatory B-domain in $\gamma$-nodule and translocation from the periphery to knob `A' triggers… 

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