• Corpus ID: 52225560

# Molecular Mechanism of Transition from Catch-Bond to Slip-Bond in Fibrin

@article{Litvinov2017MolecularMO,
title={Molecular Mechanism of Transition from Catch-Bond to Slip-Bond in Fibrin},
author={Rustem I. Litvinov and Olga Kononova and Farkhad Maksudov and Artem A. Zhmurov and Kenneth A. Marx and John W. Weisel and Valeri Barsegov},
journal={arXiv: Biological Physics},
year={2017}
}
The lifetimes of non-covalent A:a knob-hole bonds in fibrin probed with the optical trap-based force-clamp first increases ("catch bonds") and then decreases ("slip bonds") with increasing tensile force. Molecular modeling of "catch-to-slip" transition using the atomic structure of the A:a complex reveals that the movable flap serves as tension-dependent molecular switch. Flap dissociation from the regulatory B-domain in $\gamma$-nodule and translocation from the periphery to knob `A' triggers…

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