Molecular Mechanism of Androgen Action

  title={Molecular Mechanism of Androgen Action},
  author={R. Hiipakka and S. Liao},
  journal={Trends in Endocrinology & Metabolism},
  • R. Hiipakka, S. Liao
  • Published 1998
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
  • Androgens affect the growth and development of a wide variety of cell types in both males and females and produce their effects by binding to androgen receptors, which modulate the transcription of specific genes. Testosterone is the major active androgen circulating in blood, but in many tissues it is metabolized by 5alpha-reductase to 5alpha-dihydrotestosterone, which binds to and activates the androgen receptor. Androgen receptors are members of the nuclear receptor family of transcription… CONTINUE READING
    69 Citations
    Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer
    • 51
    • PDF
    Disruption of androgen receptor signaling in males by environmental chemicals
    • 126
    Androgen Action and Stress
    Molecular communication between androgen receptor and general transcription machinery
    • D. Lee, C. Chang
    • Biology, Medicine
    • The Journal of Steroid Biochemistry and Molecular Biology
    • 2003
    • 87
    Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner
    • 12
    • PDF
    Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells
    Molecular mechanisms of androgen receptor-mediated gene regulation: structure-function analysis of the AF-1 domain.
    • I. McEwan
    • Biology, Medicine
    • Endocrine-related cancer
    • 2004
    • 140
    • PDF
    Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain
    • 61


    Molecular action of androgen in the normal and neoplastic prostate.
    • 106
    From estrogen to androgen receptor: a new pathway for sex hormones in prostate.
    • 273
    • PDF
    Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer.
    • 1,208
    Syndromes of androgen resistance.
    • J. Wilson
    • Biology, Medicine
    • Biology of reproduction
    • 1992
    • 70
    • PDF
    Androgens inhibit the proliferation of a variant of the human prostate cancer cell line LNCaP
    • 40
    Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.
    • 538