Molecular MRI of liver fibrosis by a peptide-targeted contrast agent in an experimental mouse model.

@article{Chow2013MolecularMO,
  title={Molecular MRI of liver fibrosis by a peptide-targeted contrast agent in an experimental mouse model.},
  author={April M. Chow and Mingqian Tan and Darwin S. Gao and Shu Juan Fan and Jerry S. Cheung and Kwan Man and Zheng-Rong Lu and Ed X. Wu},
  journal={Investigative radiology},
  year={2013},
  volume={48 1},
  pages={46-54}
}
OBJECTIVES Cyclic decapeptide CGLIIQKNEC (CLT1) has been demonstrated to target fibronectin-fibrin complexes in the extracellular matrix of different tumors and tissue lesions. Although liver fibrosis is characterized by an increased amount of extracellular matrix consisting of fibril-forming collagens and matrix glycoconjugates such as fibronectin, we aimed to investigate the feasibility of detecting and characterizing liver fibrosis using CLT1 peptide-targeted nanoglobular contrast agent (Gd… CONTINUE READING
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