Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.

@article{Sosnovik2009MolecularMD,
  title={Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.},
  author={David E. Sosnovik and Matthias Nahrendorf and Peter Panizzi and Takashi Matsui and Elena Aikawa and Guangping Dai and Ling Li and F. E. Reynolds and Gerald W. Dorn and Ralph Weissleder and Lee Josephson and Anthony Rosenzweig},
  journal={Circulation. Cardiovascular imaging},
  year={2009},
  volume={2 6},
  pages={468-75}
}
BACKGROUND The ability to image cardiomyocyte (CM) apoptosis in heart failure could facilitate more accurate diagnostics and optimize targeted therapeutics. We thus aimed to develop a platform to image CM apoptosis quantitatively and specifically in heart failure in vivo. The myocardium in heart failure, however, is characterized by very low levels of CM apoptosis and normal vascular permeability, factors thought to preclude the use of molecular MRI. METHODS AND RESULTS Female mice with… CONTINUE READING
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