Molecular-Level Tuning of Cellular Autonomy Controls the Collective Behaviors of Cell Populations.

@article{Maire2015MolecularLevelTO,
  title={Molecular-Level Tuning of Cellular Autonomy Controls the Collective Behaviors of Cell Populations.},
  author={Th{\'e}o Maire and Hyun Soo Youk},
  journal={Cell systems},
  year={2015},
  volume={1 5},
  pages={349-60}
}
A rigorous understanding of how multicellular behaviors arise from the actions of single cells requires quantitative frameworks that bridge the gap between genetic circuits, the arrangement of cells in space, and population-level behaviors. Here, we provide such a framework for a ubiquitous class of multicellular systems-namely, "secrete-and-sense cells" that communicate by secreting and sensing a signaling molecule. By using formal, mathematical arguments and introducing the concept of a… CONTINUE READING
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