Molecular Koch's postulates applied to microbial pathogenicity.
@article{Falkow1988MolecularKP, title={Molecular Koch's postulates applied to microbial pathogenicity.}, author={S. Falkow}, journal={Reviews of infectious diseases}, year={1988}, volume={10 Suppl 2}, pages={ S274-6 } }
Microbial genetics and molecular cloning now permit us to routinely isolate specific genes from a variety of microbial pathogens. Obviously not all genes from pathogenic microorganisms play a role in pathogenicity or virulence. Just as Koch's postulates were formulated to identify the causal relationship between an organism and a specific disease, the notion is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in… CONTINUE READING
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