Molecular Koch's postulates applied to microbial pathogenicity.
@article{Falkow1988MolecularKP,
title={Molecular Koch's postulates applied to microbial pathogenicity.},
author={Stanley Falkow},
journal={Reviews of infectious diseases},
year={1988},
volume={10 Suppl 2},
pages={
S274-6
},
url={https://api.semanticscholar.org/CorpusID:13602080}
}It is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in the pathogenesis of infection and disease.
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One Reference
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