Molecular Koch's postulates applied to microbial pathogenicity.

  title={Molecular Koch's postulates applied to microbial pathogenicity.},
  author={S. Falkow},
  journal={Reviews of infectious diseases},
  volume={10 Suppl 2},
  • S. Falkow
  • Published 1988
  • Biology, Medicine
  • Reviews of infectious diseases
  • Microbial genetics and molecular cloning now permit us to routinely isolate specific genes from a variety of microbial pathogens. Obviously not all genes from pathogenic microorganisms play a role in pathogenicity or virulence. Just as Koch's postulates were formulated to identify the causal relationship between an organism and a specific disease, the notion is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in… CONTINUE READING
    548 Citations

    Topics from this paper

    Molecular Koch's postulates applied to bacterial pathogenicity — a personal recollection 15 years later
    • S. Falkow
    • Biology, Medicine
    • Nature Reviews Microbiology
    • 2004
    • 220
    • PDF
    Mycobacterium tuberculosis pathogenicity viewed through the lens of molecular Koch's postulates.
    • 8
    Bacterial genetics and molecular pathogenesis in the age of high throughput DNA sequencing.
    • 1
    Genetic manipulation of spirochetes--light at the end of the tunnel.
    • 22
    Functional genomics of pathogenic bacteria.
    • 21
    Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates.
    • 802
    • PDF
    Bacterial pathogenomics
    • 264
    • PDF


    Causation and Disease: The Henle-Koch Postulates Revisited 1
    • A. Evans
    • Biology, Medicine
    • The Yale journal of biology and medicine
    • 1976
    • 576