Molecular Koch's postulates applied to microbial pathogenicity.
@article{Falkow1988MolecularKP,
title={Molecular Koch's postulates applied to microbial pathogenicity.},
author={Stanley Falkow},
journal={Reviews of infectious diseases},
year={1988},
volume={10 Suppl 2},
pages={
S274-6
}
}Microbial genetics and molecular cloning now permit us to routinely isolate specific genes from a variety of microbial pathogens. Obviously not all genes from pathogenic microorganisms play a role in pathogenicity or virulence. Just as Koch's postulates were formulated to identify the causal relationship between an organism and a specific disease, the notion is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in…
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References
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The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments, and a set of guidelines for both acute infectious and chronic diseases is presented.