Molecular Koch's postulates applied to microbial pathogenicity.

@article{Falkow1988MolecularKP,
  title={Molecular Koch's postulates applied to microbial pathogenicity.},
  author={Stanley Falkow},
  journal={Reviews of infectious diseases},
  year={1988},
  volume={10 Suppl 2},
  pages={
          S274-6
        }
}
  • S. Falkow
  • Published 1 August 1988
  • Biology
  • Reviews of infectious diseases
Microbial genetics and molecular cloning now permit us to routinely isolate specific genes from a variety of microbial pathogens. Obviously not all genes from pathogenic microorganisms play a role in pathogenicity or virulence. Just as Koch's postulates were formulated to identify the causal relationship between an organism and a specific disease, the notion is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in… 
Molecular Koch's postulates applied to bacterial pathogenicity — a personal recollection 15 years later
  • S. Falkow
  • Biology
    Nature Reviews Microbiology
  • 2004
TLDR
These guidelines were an attempt to establish a standard for identifying the specific causation of an infectious disease and to convince sceptics that microorganisms could cause disease.
In vitro models to analyse fungal infection
TLDR
This chapter reviews the main in vitro models for epithelial, endothelial, and immune system cells and outlines the available techniques to characterize and to quantify host cell–pathogen interactions following a structure as preset by the scientists.
Functional genomics of pathogenic bacteria.
TLDR
Automated-DNA sequencing has revolutionized the investigation of pathogenic microbes by making the immense fund of information contained in their genomes available at reasonable cost, but how this information can be used to increase current understanding of the biology of commensal and virulence behaviour of pathogens is challenged.
Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates.
TLDR
A set of molecular guidelines for establishing disease causation with sequence-based technology is proposed, and the importance of the scientific concordance of evidence in supporting causal associations is emphasized.
Microbes, Molecules and Man
  • E. Moxon
  • Medicine
    Journal of the Royal College of Physicians of London
  • 1993
TLDR
Developments in molecular genetics have helped in the elucidation of the pathogenesis of meningitis caused by H influenzae and the role of type b capsule as a determinant of bacterial virulence—and satisfied the requirements of Koch's molecular postulates.
Molecular Genetic Strategies for Identifying Virulence Determinants of Mycobacterium tuberculosis
TLDR
This chapter is concerned with how knowledge of other bacterial pathogens may provide insight into the pathogenesis of tuberculosis, and the demonstration that there are significant homologs of many virulence genes of gram-negative pathogens, even in different genera will depend on fulfillment of Koch's molecular postulates.
...
1
2
3
4
5
...

References

Causation and Disease: The Henle-Koch Postulates Revisited 1
  • A. Evans
  • Medicine
    The Yale journal of biology and medicine
  • 1976
TLDR
The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments, and a set of guidelines for both acute infectious and chronic diseases is presented.