Molecular Koch's postulates applied to microbial pathogenicity.

@article{Falkow1988MolecularKP,
  title={Molecular Koch's postulates applied to microbial pathogenicity.},
  author={Stanley Falkow},
  journal={Reviews of infectious diseases},
  year={1988},
  volume={10 Suppl 2},
  pages={
          S274-6
        },
  url={https://api.semanticscholar.org/CorpusID:13602080}
}
It is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in the pathogenesis of infection and disease.

Molecular Koch's postulates applied to bacterial pathogenicity — a personal recollection 15 years later

These guidelines were an attempt to establish a standard for identifying the specific causation of an infectious disease and to convince sceptics that microorganisms could cause disease.

In vitro models to analyse fungal infection

This chapter reviews the main in vitro models for epithelial, endothelial, and immune system cells and outlines the available techniques to characterize and to quantify host cell–pathogen interactions following a structure as preset by the scientists.

Functional genomics of pathogenic bacteria.

Automated-DNA sequencing has revolutionized the investigation of pathogenic microbes by making the immense fund of information contained in their genomes available at reasonable cost, but how this information can be used to increase current understanding of the biology of commensal and virulence behaviour of pathogens is challenged.

Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates

A set of molecular guidelines for establishing disease causation with sequence-based technology is proposed, and the importance of the scientific concordance of evidence in supporting causal associations is emphasized.

Microbes, Molecules and Man

Developments in molecular genetics have helped in the elucidation of the pathogenesis of meningitis caused by H influenzae and the role of type b capsule as a determinant of bacterial virulence—and satisfied the requirements of Koch's molecular postulates.

Molecular Genetic Strategies for Identifying Virulence Determinants of Mycobacterium tuberculosis

This chapter is concerned with how knowledge of other bacterial pathogens may provide insight into the pathogenesis of tuberculosis, and the demonstration that there are significant homologs of many virulence genes of gram-negative pathogens, even in different genera will depend on fulfillment of Koch's molecular postulates.
...

Causation and Disease: The Henle-Koch Postulates Revisited 1

The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments, and a set of guidelines for both acute infectious and chronic diseases is presented.