Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei

  title={Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei},
  author={Drew A. Rholl and Krisztina M Papp-Wallace and Andrew P. Tomaras and Michael L. Vasil and Robert A. Bonomo and Herbert P. Schweizer},
  booktitle={Front. Microbio.},
Burkholderia pseudomallei is the etiological agent of melioidosis. Because of the bacterium's intrinsic resistance and propensity to establish latent infections, melioidosis therapy is complicated and prolonged. Newer generation β-lactams, specifically ceftazidime, are used for acute phase therapy, but resistance to this cephalosporin has been observed. The chromosomally encoded penA gene encodes a putative twin arginine translocase (TAT)-secreted β-lactamase, and penA mutations have been… CONTINUE READING
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Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class

  • S. Trépanier, A. Prince, A. Huletzky
  • 1997
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Microbio. 2:139. doi: 10.3389/fmicb.2011.00139 This article was submitted to Frontiers in Cellular and Infection Microbiology, a specialty of Frontiers in Microbiology

  • pseudomallei. Front
  • 2011

Molecular investigations of PenA-mediated β-lactam resistance in Burkholderia

  • DA Citation Rholl, KM Papp-Wallace, AP Tomaras, ML Vasil, RA Bonomo, HP Schweizer
  • 2011

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media

  • Rholl, Papp-Wallace, Tomaras, Vasil, Bonomo, Schweizer
  • 2011

A Burkholderia pseudomallei purM mutant is avirulent in immune competent

  • K. L. Propst, T. Mima, Choi, K.H, S. W. Dow, H. P. Schweizer
  • 2010

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