Molecular Investigation of the Mechanism of Non-Enzymatic Hydrolysis of Proteins and the Predictive Algorithm for Susceptibility.

@article{Lauer2016MolecularIO,
  title={Molecular Investigation of the Mechanism of Non-Enzymatic Hydrolysis of Proteins and the Predictive Algorithm for Susceptibility.},
  author={Timothy M Lauer and Geoffrey P. F. Wood and David C Farkas and Hasige A Sathish and Hardeep S Samra and Bernhardt L. Trout},
  journal={Biochemistry},
  year={2016},
  volume={55 23},
  pages={3315-28}
}
A number of potential degradation routes can limit the shelf life of a biotherapeutic. While these are experimentally measurable, the tests to do so require a substantial investment in both time and material, resources rarely available early in the drug development process. To address the potential degradation route of non-enzymatic hydrolysis, we performed… CONTINUE READING