Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus.

@article{Pietrocola2016MolecularIO,
  title={Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus.},
  author={Giampiero Pietrocola and Giulia Nobile and Valentina Gianotti and Marta Zapotoczna and T. J. Foster and Joan A Geoghegan and Pietro Speziale},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 35},
  pages={18148-62}
}
Staphylococcus aureus is a commensal bacterium that has the ability to cause superficial and deep-seated infections. Like several other invasive pathogens, S. aureus can capture plasminogen from the human host where it can be converted to plasmin by host plasminogen activators or by endogenously expressed staphylokinase. This study demonstrates that sortase-anchored cell wall-associated proteins are responsible for capturing the bulk of bound plasminogen. Two cell wall-associated proteins, the… CONTINUE READING
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