Molecular Interactions between Prions as Seeds and Recombinant Prion Proteins as Substrates Resemble the Biological Interspecies Barrier In Vitro

@article{Panza2010MolecularIB,
  title={Molecular Interactions between Prions as Seeds and Recombinant Prion Proteins as Substrates Resemble the Biological Interspecies Barrier In Vitro},
  author={G. Panza and L. Luers and J. St{\"o}hr and L. Nagel-Steger and J{\"u}rgen Weiβ and D. Riesner and D. Willbold and E. Birkmann},
  journal={PLoS ONE},
  year={2010},
  volume={5}
}
Prion diseases like Creutzfeldt-Jakob disease in humans, Scrapie in sheep or bovine spongiform encephalopathy are fatal neurodegenerative diseases, which can be of sporadic, genetic, or infectious origin. Prion diseases are transmissible between different species, however, with a variable species barrier. The key event of prion amplification is the conversion of the cellular isoform of the prion protein (PrPC) into the pathogenic isoform (PrPSc). We developed a sodiumdodecylsulfate-based PrP… Expand
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