Molecular Insights into the Histogenesis and Pathogenesis of Gastrointestinal Stromal Tumors.

@article{Rubin2000MolecularII,
  title={Molecular Insights into the Histogenesis and Pathogenesis of Gastrointestinal Stromal Tumors.},
  author={Brian P. Rubin and Jonathan Alfred Fletcher and Christopher D. M. Fletcher},
  journal={International journal of surgical pathology},
  year={2000},
  volume={8 1},
  pages={5-10}
}
Gastrointestinal stromal tumors (GISTs) have long been problematic in terms of classification and determination of prognosis. Recent studies have suggested that GISTs differentiate toward a phenotype resembling the interstitial cells of Cajal. This has led to the important discovery that activating mutations in the KIT receptor tyrosine kinase play an important role in the pathogenesis of GISTs. These findings have helped clarify the distinction between GISTs and other mesenchymal neoplasms of… CONTINUE READING

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