• Corpus ID: 29253904

Molecular Insights into Xenobiotic Disposition in Australian Marsupials

  title={Molecular Insights into Xenobiotic Disposition in Australian Marsupials},
  author={Adaweyah El-Merhibi and Suong Ngoc Thi Ngo and Brett R. Jones and Natalie L. Milic and Ieva Stupans and Ross A. Mckinnon},
During the past two decades, studies of xenobiotic detoxification by molecular biology in diverse organisms have identified many novel environmental adaptations, providing valuable insight into habitat, dietary preferences and general physiology. While xenobiotic detoxification has been extensively studied in eutherian mammals, metabolic data concerning detoxification in Australian marsupials are limited, particularly at the molecular level of the enzymes involved. At present Australia relies… 

Cytochrome P450 2B Diversity and Dietary Novelty in the Herbivorous, Desert Woodrat (Neotoma lepida)

This work is the most comprehensive investigation of the genetic diversity of a detoxification enzyme subfamily in a wild mammalian herbivore, and contributes an initial genetic framework to the understanding of how a wild herbivores responds to critical changes in its diet.

Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii).

Temperature-dependent toxicity in mammals with implications for herbivores: a review

  • M. Dearing
  • Environmental Science
    Journal of Comparative Physiology B
  • 2012
A model is described that integrates thermal physiology with temperature-dependent toxicity to predict maximal dietary intake of plant secondary compounds by mammalian herbivores and the effect of small changes in ambient temperature is on par with several fold changes in PSC concentration.

Chemical Traits that Predict Susceptibility of Pinus radiata to Marsupial Bark Stripping

Bark stripping by mammals is a major problem in managed conifer forests worldwide. In Australia, bark stripping in the exotic plantations of Pinus radiata is mainly caused by native marsupials and

Review of some pharmacokinetic and pharmacodynamic properties of anti‐infective medicines administered to the koala (Phascolarctos cinereus)

  • M. Govendir
  • Medicine, Biology
    Journal of veterinary pharmacology and therapeutics
  • 2018
This review addresses aspects of medicine absorption, clearance, and other indices of enrofloxacin/marbofloxac in and chloramphenicol used for the systemic treatment of chlamydiosis, and fluconazole ± amphotericin, and posaconazole for the treatment of cryptococcosis.

Rational Re-Engineering of the O-Dealkylation of 7-Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida.

Docking of 7-substituted coumarin derivatives into a model of the CYP2B35 sextuple mutant based on a previous crystal structure of the 4-(4-chlorophenyl)imidazole wild-type complex revealed how the mutant can exhibit activities of both CYP 2B35 and CYP1B37.


Nonsteroidal anti-inflammatory drugs were the most frequently used analgesics, followed by full μ- and partial opioid receptor agonists and acetaminophen with or without codeine and analgesic drug combinations were generally thought efficacious.

Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.



Xenobiotic metabolism in Australian marsupials.

The Metabolism of [14c] Phenol by Native Australian Rodents and Marsupials.

The ratios of sulphate to glucuronide conjugates suggest that carnivorous or insectivorous animals rely more on sulphuric acid for conjugation, while there is no correlation of habitat or rate of water turnover with the metabolic profile for phenol, nor is there evidence that marsupials and eutherians differ in this regard.

Metabolic fate of dietary terpenes fromEucalyptus radiata in common ringtail possum (Pseudocheirus peregrinus)

The strategy used by the possum to detoxify dietary terpenes seems to be to polyoxygenate the molecules forming highly polar, acidic metabolites that can be readily excreted.

Pharmacological Perspectives on the Detoxification of Plant Secondary Metabolites: Implications for Ingestive Behavior of Herbivores

Herbivores can use diet choice and the rate and amount of PSM consumption to prevent C from reaching a critical level that produces significant adverse effects, indicating that complex interactions are likely.

Jensenone: Biological Reactivity of a Marsupial Antifeedant from Eucalyptus

The findings suggest that the antifeedant effects of FPCs are due to their facile binding to amine groups on critical molecules in the gastrointestinal tract, leading to a loss of metabolic function.

Mixed Function Oxidases in an Australian Marsupial, the Brushtail Possum (Trichosurus vulpecula)

The factors potentially influencing the population- and sex-specific expression of cytochrome P450 isoenzymes in the brushtail possum are discussed and include exogenous dietary xenobiotics and endogenous hormonal alterations influenced by reproductive status.

Comparative Metabolism of Dietary Terpene, p-Cymene, in Generalist and Specialist Folivorous Marsupials

Findings indicate that species encountering terpenes, such as p-cymene, in their normal diet have developed efficient oxidation pathways to eliminate them and could also reduce the necessity for subsequent conjugation of metabolites which minimizes further demands on a nutritionally limited diet.

Concise review of the cytochrome P450s and their roles in toxicology.

The purpose of this current review is to highlight some of the more important mammalian P450s with respect to their expression, inducibility and inhibition character, and substrate preferences, especially as they relate to human toxicology.

Ontogenic expression of detoxication enzymes in an Australian marsupial, the brushtail possum (Trichosurus vulpecula).

  • R. BoltonJ. Ahokas
  • Biology
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 1997

Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system.

It is proposed that marsupials are ideal model organisms for the study of developmental immunology after the identification of key immune genes, including the highly divergent chemokines, defensins, cathelicidins, and Natural Killer cell receptors.