• Corpus ID: 29253904

Molecular Insights into Xenobiotic Disposition in Australian Marsupials

@inproceedings{ElMerhibi2008MolecularII,
  title={Molecular Insights into Xenobiotic Disposition in Australian Marsupials},
  author={Adaweyah El-Merhibi and Suong Ngoc Thi Ngo and Brett R. Jones and Natalie L. Milic and Ieva Stupans and Ross A. Mckinnon},
  year={2008}
}
During the past two decades, studies of xenobiotic detoxification by molecular biology in diverse organisms have identified many novel environmental adaptations, providing valuable insight into habitat, dietary preferences and general physiology. While xenobiotic detoxification has been extensively studied in eutherian mammals, metabolic data concerning detoxification in Australian marsupials are limited, particularly at the molecular level of the enzymes involved. At present Australia relies… 
ecotox.org.au
10 Citations
Background Citations
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10 Citations

Cytochrome P450 2B Diversity and Dietary Novelty in the Herbivorous, Desert Woodrat (Neotoma lepida)

This work is the most comprehensive investigation of the genetic diversity of a detoxification enzyme subfamily in a wild mammalian herbivore, and contributes an initial genetic framework to the understanding of how a wild herbivores responds to critical changes in its diet.

Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii).

Cytochrome P450 CYP3A in marsupials: cloning and characterisation of the second identified CYP3A subfamily member, isoform 3A78 from koala (Phascolarctos cinereus).

Temperature-dependent toxicity in mammals with implications for herbivores: a review

  • M. Dearing
  • Environmental Science
    Journal of Comparative Physiology B
  • 2012
A model is described that integrates thermal physiology with temperature-dependent toxicity to predict maximal dietary intake of plant secondary compounds by mammalian herbivores and the effect of small changes in ambient temperature is on par with several fold changes in PSC concentration.

Chemical Traits that Predict Susceptibility of Pinus radiata to Marsupial Bark Stripping

Bark stripping by mammals is a major problem in managed conifer forests worldwide. In Australia, bark stripping in the exotic plantations of Pinus radiata is mainly caused by native marsupials and…

Review of some pharmacokinetic and pharmacodynamic properties of anti‐infective medicines administered to the koala (Phascolarctos cinereus)

  • M. Govendir
  • Medicine, Biology
    Journal of veterinary pharmacology and therapeutics
  • 2018
This review addresses aspects of medicine absorption, clearance, and other indices of enrofloxacin/marbofloxac in and chloramphenicol used for the systemic treatment of chlamydiosis, and fluconazole ± amphotericin, and posaconazole for the treatment of cryptococcosis.

WITHDRAWN: Cytochrome P450 CYP3A in marsupials: Characterisation of the first identified CYP3A subfamily member, isoform 3A70 from Eastern grey kangaroo (Macropus giganteus).

Rational Re-Engineering of the O-Dealkylation of 7-Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida.

Docking of 7-substituted coumarin derivatives into a model of the CYP2B35 sextuple mutant based on a previous crystal structure of the 4-(4-chlorophenyl)imidazole wild-type complex revealed how the mutant can exhibit activities of both CYP 2B35 and CYP1B37.

PERCEIVED EFFICACY OF ANALGESIC DRUG REGIMENS USED FOR KOALAS (PHASCOLARCTOS CINEREUS) IN AUSTRALIA

Nonsteroidal anti-inflammatory drugs were the most frequently used analgesics, followed by full μ- and partial opioid receptor agonists and acetaminophen with or without codeine and analgesic drug combinations were generally thought efficacious.

Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.

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