Molecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria

@inproceedings{Cao2017MolecularII,
  title={Molecular Insight into the Acryloyl-CoA Hydration by AcuH for Acrylate Detoxification in Dimethylsulfoniopropionate-Catabolizing Bacteria},
  author={Hai-Yan Cao and Peng Wang and Fei Xu and Ping-Yi Li and Bin-Bin Xie and Qi-Long Qin and Yu-Zhong Zhang and Chun-yang Li and Xiu-lan Chen},
  booktitle={Front. Microbiol.},
  year={2017}
}
Microbial cleavage of dimethylsulfoniopropionate (DMSP) producing dimethyl sulfide (DMS) and acrylate is an important step in global sulfur cycling. Acrylate is toxic for cells, and thus should be metabolized effectively for detoxification. There are two proposed pathways for acrylate metabolism in DMSP-catabolizing bacteria, the AcuN-AcuK pathway and the PrpE-AcuI pathway. AcuH is an acryloyl-CoA hydratase in DMSP-catabolizing bacteria and can catalyze the hydration of toxic acryloyl-CoA to… CONTINUE READING
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