Molecular Identity of Human Outer Radial Glia during Cortical Development

  title={Molecular Identity of Human Outer Radial Glia during Cortical Development},
  author={Alex A Pollen and Tomasz J Nowakowski and Jiadong Chen and Hanna E G Retallack and Carmen Sandoval-Espinosa and Cory R. Nicholas and Joe Shuga and Siyuan John Liu and Michael C. Oldham and Aaron Diaz and Daniel A. Lim and Anne A. Leyrat and Jay A West and Arnold R Kriegstein},
Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer subventricular zone radial glia may generate the majority of human cortical neurons, their molecular features remain elusive. By analyzing gene expression across single cells, we find that outer radial glia preferentially express genes related to extracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR… CONTINUE READING
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