Molecular Identification of a Malaria Merozoite Surface Sheddase

  title={Molecular Identification of a Malaria Merozoite Surface Sheddase},
  author={P. K. Harris and S. Yeoh and A. Dluzewski and R. O’Donnell and C. Withers-Martinez and F. Hackett and L. Bannister and G. H. Mitchell and M. Blackman},
  journal={PLoS Pathogens},
  • P. K. Harris, S. Yeoh, +6 authors M. Blackman
  • Published 2005
  • Biology, Medicine
  • PLoS Pathogens
  • Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptor complexes in order to gain entry into their host cell. Erythrocyte invasion by merozoites of the malaria parasite Plasmodium falciparum requires the shedding of ectodomain components of two essential surface proteins, called MSP1 and AMA1. Both are released by the same merozoite surface “sheddase,” but… CONTINUE READING
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