Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice

@article{Kamimura2011MolecularHI,
  title={Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice},
  author={Naomi Kamimura and Kiyomi Nishimaki and Ikuroh Ohsawa and Shigeo Ohta},
  journal={Obesity},
  year={2011},
  volume={19}
}
Recent extensive studies have revealed that molecular hydrogen (H(2)) has great potential for improving oxidative stress-related diseases by inhaling H(2) gas, injecting saline with dissolved H(2), or drinking water with dissolved H(2) (H(2)-water); however, little is known about the dynamic movement of H(2) in a body. [...] Key Result Drinking H(2)-water reduced hepatic oxidative stress, and significantly alleviated fatty liver in db/db mice as well as high fat-diet-induced fatty liver in wild-type mice.Expand
Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity Mice
TLDR
The results of a colony formation assay of bone-marrow-derived endothelial progenitor cells (EPCs) indicated that MHW activated the expansion, differentiation, and mobilization of EPCs to maintain vascular homeostasis and exerts cardiovascular protective effects in DIO mice. Expand
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
TLDR
H2 induces expression of the PGC-1α gene, followed by stimulation of the PPARα pathway that regulates FGF21, and the fatty acid and steroid metabolism, which improved the level of plasma triglycerides and extended the average of lifespan in wild-type mice fed a fatty diet. Expand
Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle
TLDR
It is demonstrated that H2 exerts metabolic effects similar to those of insulin and may be a novel therapeutic alternative to insulin in type 1 diabetes mellitus that can be administered orally. Expand
The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus.
TLDR
Patients with T2DM may be able to improve their condition by supplementing HW as daily drinking water, which suppressed the increase in glucose, total cholesterol, oxidative stress, and inflammation and ameliorates hyperglycemia-induced liver, kidney, and spleen dysfunction. Expand
Oral ‘hydrogen water' induces neuroprotective ghrelin secretion in mice
TLDR
The neuroprotective effect of H2 water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys3 GHRP-6, or atenolol, and this work shows that H2 supplementation increases gastric expression of mRNA encoding gh Relin, a growth hormone secretagogue, and ghrelIn secretion, which are antagonized by the β1-adrenoceptor blocker, atenalol. Expand
Oxygenated Water Inhibits Adipogenesis and Attenuates Hepatic Steatosis in High-Fat Diet-Induced Obese Mice
TLDR
Evidence is provided regarding OW’s effects on adipogenesis and mature adipocytes, and the corresponding molecular mechanisms, which exhibits transient triglyceride-lowering and glucose tolerance-improving activity as well as hepatic steatosis-attenuating functions. Expand
Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ.
TLDR
It is concluded that H2‑rich saline had significant therapeutic effects on NAFLD induced by hyperglycemia and hyperlipidemia, as demonstrated by hematoxylin and eosin and terminal deoxynucleotidyl-transferase‑mediated dUTP nick end labeling staining. Expand
Hydrogen: An Endogenous Regulator of Liver Homeostasis
TLDR
Liver has the highest concentration of H2 after supplement of exogenous H2 by various strategies in vivo and may play essential roles in maintaining liver homeostasis, while enhanced endogenous H2 production may improve hepatitis, hepatic ischemia and reperfusion injury, liver regeneration, and hepatic steatosis. Expand
Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents
TLDR
It is found that the combination of both HRW and HCA had the most potent effects on signaling pathways and gene expression in systemic organs, suggesting that H2 may act not only through a dose-dependent mechanism but also through a complex molecular network. Expand
Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model
TLDR
H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice and demonstrates a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.
TLDR
Consumption of H(2)-dissolved water at a saturated level (H(2-water) ad libitum prevents arteriosclerosis using an apolipoprotein E knockout mouse (apoE(-/-)), a model of the spontaneous development of atherosclerosis. Expand
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
TLDR
Exposure to hydrogen-rich water may have a beneficial role in prevention of type 2 diabetes mellitus and insulin resistance and four patients with IGT normalized the oral glucose tolerance test. Expand
Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice
TLDR
Continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint, which is applicable for preventive use in cognitive or other neuronal disorders. Expand
Impact of Oxidative Stress and Peroxisome Proliferator–Activated Receptor γ Coactivator-1α in Hepatic Insulin Resistance
TLDR
The results indicate that the reduction of ROS is a potential therapeutic target of liver insulin resistance, at least partly by the reduced expression of PGC-1α. Expand
Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study
TLDR
Drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome and the portable magnesium stick was a safe, easy and effective method of delivering hydrogen richWater for daily consumption by participants in the study. Expand
Oral hydrogen water prevents chronic allograft nephropathy in rats.
TLDR
Oral HW is an effective antioxidant and antiinflammatory agent that prevented CAN, improved survival of rat renal allografts, and may be of therapeutic value in the setting of transplantation. Expand
FGF-21 as a novel metabolic regulator.
TLDR
It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes. Expand
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.
TLDR
Inhalation of hydrogen gas is proposed as a widely applicable method to reduce oxidative stress and reduced levels of serum alanine aminotransferase and hepatic malondialdehyde, and helium gas showed no protective effect, suggesting that the protective effect by hydrogenGas is specific. Expand
The Molecular Genetics of Rodent Single Gene Obesities*
TLDR
By virtue of their effects on critical regulatory pathways of energy homeostasis, the rodent single gene obesities represent complex admixtures of these mechanisms and provide important insights into the molecular physiology of weight regulation. Expand
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice
TLDR
It is shown that hydrogen efficiently mitigates the side effects of cisplatin by reducing oxidative stress and improving mortality and body-weight loss caused by cisPlatin, and alleviated nephrotoxicity. Expand
...
1
2
3
4
...