Molecular Heterogeneity in Aldosterone-Producing Adenomas.

  title={Molecular Heterogeneity in Aldosterone-Producing Adenomas.},
  author={Kazutaka Nanba and Andrew X. Chen and Kei Omata and Michelle L Vinco and Thomas J. Giordano and Tobias Else and Gary D Hammer and Scott Arthur Tomlins and William E. Rainey},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={101 3},
CONTEXT The use of next-generation sequencing has resulted in the identification of recurrent somatic mutations underlying primary aldosteronism (PA). However, significant gaps remain in our understanding of the relationship between tumor aldosterone synthase (CYP11B2) expression and somatic mutation status. OBJECTIVE The objective of the study was to investigate tumor CYP11B2 expression and somatic aldosterone-driver gene mutation heterogeneity. METHODS Fifty-one adrenals from 51 PA… CONTINUE READING
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