Molecular Genetics and Evolution of Melanism in the Cat Family

@article{Eizirik2003MolecularGA,
  title={Molecular Genetics and Evolution of Melanism in the Cat Family},
  author={E. Eizirik and N. Yuhki and W. Johnson and M. Menotti-Raymond and S. Hannah and S. O'Brien},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={448-453}
}
Melanistic coat coloration occurs as a common polymorphism in 11 of 37 felid species and reaches high population frequency in some cases but never achieves complete fixation. To investigate the genetic basis, adaptive significance, and evolutionary history of melanistic variants in the Felidae, we mapped, cloned, and sequenced the cat homologs of two putative candidate genes for melanism (ASIP [agouti] and MC1R) and identified three independent deletions associated with dark coloration in three… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
The molecular basis of an avian plumage polymorphism in the wild A melanocortin-1-receptor point mutation is perfectly associated with the melanic plumage morph of the bananaquit, Coereba flaveola
TLDR
It is concluded that a mutation in the melanocortin-1 receptor is responsible for the plumage polymorphism in a wild bird population and that the melanic MC1R alleles in Grenada and St. Vincent bananaquit populations have a single evolutionary origin from a yellow allele. Expand
Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)
TLDR
Using cross-species techniques, cloned, sequenced, and characterized equine melanocortin-1-receptor (MC1R) and agouti-signaling-protein (ASIP) and completed a partial sequence of tyrosinase-related protein 1 (TYRP1). Expand
Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.
TLDR
Short and long-range restriction enzyme analyses of homozygous a 18H DNA are consistent with the hypothesis that a18H results from a paracentric inversion where one end of the inversion maps in the 5' regulatory region of agouti and the other end in or near a gene that is required for normal immunological function. Expand
Melanocortin receptor 1 (MC1R) mutations and coat color in pigs.
TLDR
Sequence analysis of MC1R from seven porcine breeds revealed a total of four allelic variants corresponding to five different E alleles, which suggest that one of these, L99P, may form a constitutively active receptor. Expand
Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
TLDR
It is shown here that the murine extension locus encodes the melanocyte-stimulating hormone (MSH) receptor, and that the Eso-3J receptor is constitutively activated, while the Etob receptor remains hormone responsive and produces a greater activation of its effector than does the wild-type allele. Expand
A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the chicken.
TLDR
The finding that the structure of MC1-R was affected by individual E-locus alleles strongly suggests that MC1 -R is associated with the E- locus. Expand
Molecular and pharmacological characterization of dominant black coat color in sheep
TLDR
The pharmacological profile of the M73K change is unique compared to the constitutively active E92K mutation in the sombre mouse and C123R mutation inThe Alaska silver fox, indicating that the M 73K change activates the receptor via a mechanism distinct from these previously characterized mutations. Expand
A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes
TLDR
The results, demonstrating the presence of dominant extension alleles in foxes with significant red coat colouration, suggest the ability of the fox agouti protein to counteract the signalling activity of a constitutively active fox MC1R. Expand
Melanocortin 1 receptor variation in the domestic dog
TLDR
The results indicate that the e allele is caused by a common Mc1r loss-of-function mutation that either reoccurred or was subject to gene conversion during recent evolutionary history, and suggest that the allelic and locus relationships for dog coat color genes may be more analogous to those found in other mammals than previously thought. Expand
The genetics of pigmentation: from fancy genes to complex traits.
  • G. Barsh
  • Biology, Medicine
  • Trends in genetics : TIG
  • 1996
TLDR
Genes that control mammalian pigmentation interact with each other in intricate networks that have been studied for decades using mouse coat color mutations, leading to surprising new insights into the potential interaction between tyrosine kinase and G-protein-coupled signaling pathways. Expand
...
1
2
3
...