Molecular Genetics and Evolution of Melanism in the Cat Family

@article{Eizirik2003MolecularGA,
  title={Molecular Genetics and Evolution of Melanism in the Cat Family},
  author={E. Eizirik and N. Yuhki and W. Johnson and M. Menotti-Raymond and S. Hannah and S. O'Brien},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={448-453}
}
  • E. Eizirik, N. Yuhki, +3 authors S. O'Brien
  • Published 2003
  • Biology, Medicine
  • Current Biology
  • Melanistic coat coloration occurs as a common polymorphism in 11 of 37 felid species and reaches high population frequency in some cases but never achieves complete fixation. To investigate the genetic basis, adaptive significance, and evolutionary history of melanistic variants in the Felidae, we mapped, cloned, and sequenced the cat homologs of two putative candidate genes for melanism (ASIP [agouti] and MC1R) and identified three independent deletions associated with dark coloration in three… CONTINUE READING
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