Molecular Genetic Analysis of Ethanol Intoxication in Drosophila melanogaster1

  title={Molecular Genetic Analysis of Ethanol Intoxication in Drosophila melanogaster1},
  author={U. Heberlein and F. W. Wolf and A. Rothenfluh and D. Guarnieri},
  booktitle={Integrative and comparative biology},
Abstract Recently, the fruit fly Drosophila melanogaster has been introduced as a model system to study the molecular bases of a variety of ethanol-induced behaviors. It became immediately apparent that the behavioral changes elicited by acute ethanol exposure are remarkably similar in flies and mammals. Flies show signs of acute intoxication, which range from locomotor stimulation at low doses to complete sedation at higher doses and they develop tolerance upon intermittent ethanol exposure… Expand
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