Molecular Genetic Analysis of Ethanol Intoxication in Drosophila melanogaster1

  title={Molecular Genetic Analysis of Ethanol Intoxication in Drosophila melanogaster1},
  author={Ulrike Heberlein and Fred W. Wolf and Adrian Rothenfluh and Douglas J. Guarnieri},
  booktitle={Integrative and comparative biology},
Abstract Recently, the fruit fly Drosophila melanogaster has been introduced as a model system to study the molecular bases of a variety of ethanol-induced behaviors. It became immediately apparent that the behavioral changes elicited by acute ethanol exposure are remarkably similar in flies and mammals. Flies show signs of acute intoxication, which range from locomotor stimulation at low doses to complete sedation at higher doses and they develop tolerance upon intermittent ethanol exposure… 

The evolution of Drosophila melanogaster as a model for alcohol research.

The ecological relationship between flies and ethanol, the effects of ethanol on fly development and behavior, the use of flies as a model for alcohol addiction, and the interaction between ethanol and social behavior are described.

Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.

These analyses strongly suggest that the Drosophila and C. elegans models have considerable utility for identifying orthologs of genes that influence human AUD.

Gene regulation in Drosophila melanogaster in response to an acute dose of ethanol

These studies have demonstrated that microarray analysis is an efficient method for identifying candidate genes and pathways that may be fundamental to human alcohol dependence or abuse.

Genetic approaches to alcohol addiction: gene expression studies and recent candidates from Drosophila

Data from several research groups using high-throughput gene expression profiling to search for alcohol-responsive genes in Drosophila melanogaster support the view that changes in gene expression in alcoholics are associated with widespread cellular functions.

Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster

It is found that while D. melanogaster responds to ethanol, there is very little genetic variation in how it responds toanol, suggesting that incorporating time into studies on the response to the environment is important.

Contrasting Roles of Cannabidiol as an Insecticide and Rescuing Agent for Ethanol–induced Death in the Tobacco Hornworm Manduca sexta

The results show CBDs’ defensive role against pest insects, which suggests its possible use as an insecticide, and evidence that CBD alleviates alcohol-induced stress is provided.

Bumblebee death associated with Tilia x europaea L



Drosophila melanogaster, a genetic model system for alcohol research.

Genetic control of acute ethanol-induced behaviors in Drosophila.

The analysis of mutants with altered sensitivity to ethanol revealed that the genetic pathways which regulate these responses are complex and that single genes can affect hyperactivity, turning, and sedation independently.

Functional Dissection of Neuroanatomical Loci Regulating Ethanol Sensitivity in Drosophila

It is concluded that the regulation of ethanol-induced behaviors by PKA involves complex interactions among groups of cells that mediate either increased or reduced sensitivity to the acute intoxicating effects of ethanol.

Functional Ethanol Tolerance in Drosophila

High-Resolution Analysis of Ethanol-Induced Locomotor Stimulation in Drosophila

The effects of ethanol on locomotion are comparable in flies and mammals, suggesting that Drosophila is a suitable model system to study the underlying mechanisms of ethanol action and alcoholism.

A genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity to halothane.

  • K. KrishnanH. Nash
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
In an attempt to identify genes that control or encode the targets of general anesthetics, chemically mutagenized fruit flies and selected four lines that show an abnormal response to the volatile anesthetic halothane, fine mapping of two isolates indicates that they alter a previously uncharacterized gene of Drosophila.

Invertebrate models of drug abuse.

Recent behavioral and genetic studies in flies and worms on the effects of ethanol, cocaine, and nicotine, three of the most widely abused drugs in the world are reviewed.