Molecular Evolution of Viral Multifunctional Proteins: The Case of Potyvirus HC-Pro

@article{HasiwJaroszewska2013MolecularEO,
  title={Molecular Evolution of Viral Multifunctional Proteins: The Case of Potyvirus HC-Pro},
  author={Beata Hasi{\'o}w-Jaroszewska and Mario A. Fares and Santiago F. Elena},
  journal={Journal of Molecular Evolution},
  year={2013},
  volume={78},
  pages={75-86}
}
Our knowledge on the mode of evolution of the multifunctional viral proteins remains incomplete. To tackle this problem, here, we have investigated the evolutionary dynamics of the potyvirus multifunctional protein HC-Pro, with particular focus on its functional domains. The protein was partitioned into the three previously described functional domains, and each domain was analyzed separately and assembled. We searched for signatures of adaptive evolution and evolutionary dependencies of amino… CONTINUE READING

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