Molecular Evolution of Keap 1 : Two Keap 1 Molecules with Distinctive IVR Structures are Conserved among Fish

@inproceedings{Li2008MolecularEO,
  title={Molecular Evolution of Keap 1 : Two Keap 1 Molecules with Distinctive IVR Structures are Conserved among Fish},
  author={Li Li and Makoto Kobayashi and Hiroshi Kaneko and Yaeko Nakajima-Takagi and Yuko Nakayama and Masayuki Yamamoto},
  year={2008}
}
Keap1 is a BTB-Kelch type substrate adaptor protein of the Cul3-dependent ubiquitin ligase complex. Keap1 facilitates the degradation of Nrf2, a transcription factor regulating the inducible expression of many cytoprotective genes. Through comparative genome analyses, we found that amino acid residues comprising the pocket of Keap1 that interacts with Nrf2 are highly conserved among Keap1 orthologs and related proteins in all vertebrates and in certain invertebrates, including flies and… CONTINUE READING