Molecular Evolution Within the L-Malate and L-Lactate Dehydrogenase Super-Family

  title={Molecular Evolution Within the L-Malate and L-Lactate Dehydrogenase Super-Family},
  author={D. Madern},
  journal={Journal of Molecular Evolution},
  • D. Madern
  • Published 2001
  • Biology, Medicine
  • Journal of Molecular Evolution
  • Abstract. The NAD(P)-dependent malate (L-MalDH) and NAD-dependent lactate (L-LDH) form a large super-family that has been characterized in organisms belonging to the three domains of life. In the first part of this study, the group of [LDH-like] L-MalDH, which are malate dehydrogenases resembling lactate dehydrogenase, were analyzed and clearly defined with respect to the other enzymes. In the second part, the phylogenetic relationships of the whole super-family were presented by taking into… CONTINUE READING
    92 Citations
    Functional characterization of an alternative [lactate dehydrogenase-like] malate dehydrogenase in Plasmodium falciparum
    • 22
    • Highly Influenced
    Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases
    • 16
    A new family of NAD(P)H-dependent oxidoreductases distinct from conventional Rossmann-fold proteins.
    • 13
    Crystal structure and biochemical characterization of malate dehydrogenase from Metallosphaera sedula.
    • 2


    Malate/lactate dehydrogenase in mollicutes: evidence for a multienzyme protein.
    • 40
    Differences in the oligomeric states of the LDH-like L-MalDH from the hyperthermophilic archaea Methanococcus jannaschii and Archaeoglobus fulgidus.
    • 16
    A specific, highly active malate dehydrogenase by redesign of a lactate dehydrogenase framework.
    • 246
    Two malate dehydrogenases in Methanobacterium thermoautotrophicum
    • 26
    Malate dehydrogenase: A model for structure, evolution, and catalysis
    • 188
    • Highly Influential
    • PDF
    Primary Structure and Phylogenetic Relationships of a Malate Dehydrogenase Gene from Giardia lamblia
    • 36
    • Highly Influential
    Lactate dehydrogenase (LDH) gene duplication during chordate evolution: the cDNA sequence of the LDH of the tunicate Styela plicata.
    • 25
    • PDF
    Convergent evolution of Trichomonas vaginalis lactate dehydrogenase from malate dehydrogenase.
    • 110
    • Highly Influential
    • PDF
    The putative l‐lactate dehydrogenase from Methanococcus jannaschii is an NADPH‐dependent l‐malate dehydrogenase
    • D. Madern
    • Biology, Medicine
    • Molecular microbiology
    • 2000
    • 15