Molecular Engineering of Therapeutic Cytokines

@inproceedings{VazquezLombardi2013MolecularEO,
  title={Molecular Engineering of Therapeutic Cytokines},
  author={Rodrigo Vazquez-Lombardi and Brendan Roome and Daniel Christ},
  year={2013}
}
Over the past three decades, a large body of work has been directed at the development of therapeutic cytokines. Despite their central role in immune modulation, only a handful of cytokine therapeutics has achieved regulatory approval. One of the major challenges associated with the therapeutic use of cytokines relates to their short serum half-life and low bioavailability. High doses are required to overcome these problems, which often result in dose-limiting toxicities. Consequently, most… CONTINUE READING
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