Molecular Dynamics Study of Twister Ribozyme: Role of Mg2+ Ions and the Hydrogen-Bonding Network in the Active Site

Abstract

The recently discovered twister ribozyme is thought to utilize general acid-base catalysis in its self-cleavage mechanism, but the roles of nucleobases and metal ions in the mechanism are unclear. Herein, molecular dynamics simulations of the env22 twister ribozyme are performed to elucidate the structural and equilibrium dynamical properties, as well as to… (More)
DOI: 10.1021/acs.biochem.6b00203

Topics

12 Figures and Tables

Cite this paper

@inproceedings{Ucisik2016MolecularDS, title={Molecular Dynamics Study of Twister Ribozyme: Role of Mg2+ Ions and the Hydrogen-Bonding Network in the Active Site}, author={Melek N. Ucisik and Philip C. Bevilacqua and Sharon Hammes-Schiffer}, booktitle={Biochemistry}, year={2016} }