Molecular Dynamics Simulations of GABA Binding to the GABAC Receptor: The Role of Arg104

@article{Melis2008MolecularDS,
  title={Molecular Dynamics Simulations of GABA Binding to the GABAC Receptor: The Role of Arg104},
  author={Claudio Melis and Sarah C. R. Lummis and Carla Molteni},
  journal={Biophysical Journal},
  year={2008},
  volume={95},
  pages={4115 - 4123}
}
GABA is the major inhibitory neurotransmitter in the nervous system and acts at a variety of receptors including GABAC receptors, which are a subclass of GABAA receptors. Here we have used molecular dynamics simulations of GABA docked into the extracellular domain of the GABAC receptor to explain the molecular interactions of the neurotransmitter with the residues that contribute to the binding site; in particular, we have explored the interaction of GABA with Arg104. The simulations suggest… CONTINUE READING

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