Molecular Dynamic Simulations Reveal the Structural Determinants of Fatty Acid Binding to Oxy-Myoglobin

@inproceedings{Chintapalli2015MolecularDS,
  title={Molecular Dynamic Simulations Reveal the Structural Determinants of Fatty Acid Binding to Oxy-Myoglobin},
  author={Sree V. Chintapalli and Gaurav Bhardwaj and Reema Patel and Natasha F Shah and Randen L. Patterson and Damian B. van Rossum and Andriy Anishkin and Sean H Adams and Paolo Carloni},
  booktitle={PloS one},
  year={2015}
}
The mechanism(s) by which fatty acids are sequestered and transported in muscle have not been fully elucidated. A potential key player in this process is the protein myoglobin (Mb). Indeed, there is a catalogue of empirical evidence supporting direct interaction of globins with fatty acid metabolites; however, the binding pocket and regulation of the… CONTINUE READING