Molecular Docking of Seed Bioactives as Dual COX-2 and LOX-3 Inhibitors in Context to Osteoarthritis

  title={Molecular Docking of Seed Bioactives as Dual COX-2 and LOX-3 Inhibitors in Context to Osteoarthritis},
  author={L. Jeeva Jothi and Asma Saqib and Chandrakant Shivappa Karigar and Shailasree Sekhar},
  journal={Pharmacognosy Communications},
Introduction: Potent anti-inflammatory seed bioactives through dual inhibition of cyclooxygenase (COX)-2 and lipoxygenase (LOX)-3 were evaluated by a computational approach, routinely used to reduce cost and time in drug discovery. Methods: The strategy employed in this study could be split into the two categories of screening and docking. Results: The analysis resulted in seven Lipinski compliant hits (epicatechin, 3, 4-Dihydroxy phenyl acetic acid, gallic acid, 3, 4-Dihydroxy benzoate… 

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