• Corpus ID: 212550993

Molecular Docking Studies of Rutin on Matrix Metalloproteinase

  title={Molecular Docking Studies of Rutin on Matrix Metalloproteinase},
  author={Gurudeeban Selvaraj and Satyavani Kaliamurthi and Ramanathan and Thiruganasambandam},
Matrix metalloproteinase (MMP) also known as matrixins, play an important role in wound healing, tissue engineering and embryogenesis. The action of MMP inhibited by several endogenous tissue inhibitors but the pathological condition requires exogenous inhibitor from natural or synthetic source. Therefore, the present study is aimed to evaluate the inhibitory effect of rutin on metalloproteinase. The active sites of target proteins were predicted through 3DLignadsite. Based on the Lamarckian… 

Figures and Tables from this paper

Molecular Docking Analysis of Chlorogenic Acid Against Matrix Metalloproteinases (MMPs)

The result of docking studies showed that chlorogenic acid showed an excellent binding affinity towards all four selected MMPs, and can be used to regulate the activity of metalloproteinases and help to promote wound healing activity.

The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

Rutin is a promising natural dietary compound with promising anticancer potential and can be widely used in functional foods, dietary supplements, and pharmaceuticals for the prevention and management of cancer.

An In-silico Approach to Explore the Possible Multifunctional Neuroprotective Efficacy of Violacein against Ischemic Stroke

Violacein with its high antioxidant and anti-inflammatory property can be a potent all round treatment for cerebral ischemia and demands extensive research.

The Anti-Photoaging Activity of Peptides from Pinctada martensii Meat

Results showed that peptides from Pinctada martensii meat increased UVB-induced cell viability and reduced the contents of interstitial collagenase and matrix lysing enzyme in HaCaT cells, and might have the potential to be used as an anti-photoaging agent in functional foods.

Anti-Wrinkle Effect of Isatis indigotica Leaf Extract: Evaluation of Antioxidant, Anti-Inflammation, and Clinical Activity

In a clinical trial, five roughness values of visiometer and visual score were significantly reduced in treated groups compared with the placebo group after 8 weeks, indicating that I. indigotica leaf extract inhibits wrinkle formation, and could be a potential anti-wrinkle agent.



Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells.

Findings indicate that flavonoids from blueberry possess the ability to effectively decrease MMP activity, which may decrease overall ECM degradation, which is important in controlling tumor metastasis formation.

How matrix metalloproteinases regulate cell behavior.

Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled.

Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases.

An up-to date review of targeted mutagenesis studies of matrix metalloproteinases implicated in collagen breakdown that contributes to joint destruction of rheumatoid arthritis and osteoarthritis is presented.

Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas

The data suggest that gelatinase-A, -B and MT1-MMP are important in the pathophysiology of human gliomas, although the primary role of gelatin enzyme-B may lie in remodelling associated with neovascularization, whereas gelatinase’s role may be involved in both glial invasion and angiogenesis.

Patterns of MMP-2 and MMP-9 expression in human cancer cell lines.

The aim of this study was to examine the effect of PMA on MMP-2 and M MP-9 secretion in 42 different human cancer cell lines, selected on the basis of their organ malignancies.

Metalloproteinases and their inhibitors: regulators of wound healing.

  • S. GillW. Parks
  • Biology
    The international journal of biochemistry & cell biology
  • 2008

Elastase Release by Stimulated Neutrophils Inhibited by Flavonoids: Importance of the Catechol Group

The results of the present study suggest that quercetin may be a promising therapeutic agent in the treatment of neutrophil-dependent inflammatory diseases.

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention.

Understanding the cellular events involved in angiogenesis and the molecular regulation of these events has enormous clinical implications and is providing novel therapeutic targets for the treatment of a variety of diseases, including cancer.

Dipeptidyl peptidase IV inhibitors derived from a mangrove flora Rhizophora mucronata : An in silico approach

To isolate and evaluate cystine, phenyl acetic acid, acrylamide, caprylone and oleic acid from Rhizophora mucronata inhibitory action on DPP IV inhibitors using in silico approach, cysteine acts as an inhibitor with binding energy -5.89 kcal/mol.