Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists

@inproceedings{Noha2017MolecularDM,
  title={Molecular Docking, Molecular Dynamics, and Structure–Activity
Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones
as Potent μ-Opioid Receptor Agonists},
  author={Stefan M. Noha and Helmut Schmidhammer and Mariana Spetea},
  booktitle={ACS chemical neuroscience},
  year={2017}
}
Among opioids, morphinans are of major importance as the most effective analgesic drugs acting primarily via μ-opioid receptor (μ-OR) activation. Our long-standing efforts in the field of opioid analgesics from the class of morphinans led to N-methylmorphinan-6-ones differently substituted at positions 5 and 14 as μ-OR agonists inducing potent analgesia and… CONTINUE READING