Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie

Abstract

Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.

DOI: 10.3201/eid1704.101215

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@inproceedings{Pirisinu2011MolecularDO, title={Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie}, author={Laura Pirisinu and Sergio Migliore and Michele Angelo Di Bari and Elena Esposito and Thierry Baron and Claudia D’Agostino and Luigi De Grossi and Gabriele Vaccari and Umberto Agrimi and Romolo Nonno}, booktitle={Emerging infectious diseases}, year={2011} }