Molecular Diagnostic and Prognostic Subtyping of Gliomas in Tunisian Population

@article{Trabelsi2016MolecularDA,
  title={Molecular Diagnostic and Prognostic Subtyping of Gliomas in Tunisian Population},
  author={Saoussen Trabelsi and Imen Chabchoub and Iadh Ksira and Nadhir Karmeni and Nadia Mama and Samia Belajouza Kanoun and Anna Burford and Alexa Jury and Alan Mackay and Sergey Popov and Noureddine Bouaouina and Slim Ben Ahmed and Moncef Mokni and Kalthoum Tlili and H{\'e}di Krifa and Mohamed Yacoubi and Chris Jones and Ali Kandil Saad and Dorra H’mida Ben Brahim},
  journal={Molecular Neurobiology},
  year={2016},
  volume={54},
  pages={2381-2394}
}
It has become increasingly evident that morphologically similar gliomas may have distinct clinical phenotypes arising from diverse genetic signatures. To date, glial tumours from the Tunisian population have not been investigated. To address this, we correlated the clinico-pathology with molecular data of 110 gliomas by a combination of HM450K array, MLPA and TMA-IHC. PTEN loss and EGFR amplification were distributed in different glioma histological groups. However, 1p19q co-deletion and… CONTINUE READING
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