Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma

@article{Rosenwald2003MolecularDO,
  title={Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma},
  author={Andreas Rosenwald and George W. Wright and Karen Leroy and Xin Yu and Philippe Gaulard and Randy D. Gascoyne and Wing Chung Chan and Tong Zhao and Corinne Haioun and Timothy C. Greiner and Dennis D. Weisenburger and James C. Lynch and Julie Marie Vose and James Olen Armitage and Erlend Smeland and Stein O Kvaloy and Harald Holte and Jan Delabie and El{\'i}as Campo and Emili Montserrat and Armando L{\'o}pez-Guillermo and German Ott and Hans Konrad Muller-Hermelink and Joseph M. Connors and Rita M. Braziel and Thomas M. Grogan and Richard I. Fisher and Thomas P. Miller and Michael LeBlanc and Michael Chiorazzi and Haishuang Zhao and Liming Yang and John Powell and Wyndham H. Wilson and Elaine S. Jaffe and Richard M. Simon and Richard D. Klausner and Louis M. Staudt},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={198},
  pages={851 - 862}
}
Using current diagnostic criteria, primary mediastinal B cell lymphoma (PMBL) cannot be distinguished from other types of diffuse large B cell lymphoma (DLBCL) reliably. We used gene expression profiling to develop a more precise molecular diagnosis of PMBL. PMBL patients were considerably younger than other DLBCL patients, and their lymphomas frequently involved other thoracic structures but not extrathoracic sites typical of other DLBCLs. PMBL patients had a relatively favorable clinical… CONTINUE READING
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