Molecular Determinants of Metabotropic Glutamate Receptor 1B Trafficking

@article{Chan2001MolecularDO,
  title={Molecular Determinants of Metabotropic Glutamate Receptor 1B Trafficking},
  author={W. Chan and M. Soloviev and F. Ciruela and R. Mcilhinney},
  journal={Molecular and Cellular Neuroscience},
  year={2001},
  volume={17},
  pages={577-588}
}
The metabotropic glutamate receptor mGluR1 undergoes alternative splicing to generate isoforms differing in C-terminal sequence. The mechanism by which these isoforms give different functional responses to agonists in vitro is so far unclear. Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b. Its presence results in… Expand
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References

SHOWING 1-10 OF 50 REFERENCES
A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover
Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.
Characterization of the Dimerization of Metabotropic Glutamate Receptors Using an N‐Terminal Truncation of mGluR1α
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1
The C‐Terminal Domain of the mGluR1 Metabotropic Glutamate Receptor Affects Sensitivity to Agonists
The metabotropic GABA receptor: molecular insights and their functional consequences
Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors
Immunocytochemical localization of the mGluR1b metabotropic glutamate receptor in the rat hypothalamus
A family of metabotropic glutamate receptors
...
1
2
3
4
5
...