Molecular Determinants of Metabotropic Glutamate Receptor 1B Trafficking

@article{Chan2001MolecularDO,
  title={Molecular Determinants of Metabotropic Glutamate Receptor 1B Trafficking},
  author={Wai-Yee Chan and M. M. Soloviev and Francisco Ciruela and R. A. J. Mcilhinney},
  journal={Molecular and Cellular Neuroscience},
  year={2001},
  volume={17},
  pages={577-588}
}
The metabotropic glutamate receptor mGluR1 undergoes alternative splicing to generate isoforms differing in C-terminal sequence. The mechanism by which these isoforms give different functional responses to agonists in vitro is so far unclear. Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b. Its presence results in… 

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