Molecular Determinants in Phagocyte-Bacteria Interactions.

  title={Molecular Determinants in Phagocyte-Bacteria Interactions.},
  author={Stefan H. E. Kaufmann and Anca Dorhoi},
  volume={44 3},
Phagocytes are crucial for host defense against bacterial pathogens. As first demonstrated by Metchnikoff, neutrophils and mononuclear phagocytes share the capacity to engulf, kill, and digest microbial invaders. Generally, neutrophils focus on extracellular, and mononuclear phagocytes on intracellular, pathogens. Reciprocally, extracellular pathogens often capitalize on hindering phagocytosis and killing of phagocytes, whereas intracellular bacteria frequently allow their engulfment and then… CONTINUE READING
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