Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation

  title={Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation},
  author={Donna Collins-McMillen and Jason C Buehler and Megan Peppenelli and F. Goodrum},
  • Donna Collins-McMillen, Jason C Buehler, +1 author F. Goodrum
  • Published 2018
  • Biology, Medicine
  • Viruses
  • Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long persistence in the host, like all herpesviruses, by way of a latent infection. During latency, viral genomes are maintained in a quieted state. Virus replication can be reactivated from latency in response to changes in cellular signaling caused by stress or differentiation. The past decade has brought great insights into the molecular basis of HCMV latency. Here, we review the complex persistence of HCMV with… CONTINUE READING
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